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human KIF7 shRNA silencing AAV

Name 
AAV-h-KIF7-shRNA
Cat No 
shAAV-213114
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KIF7.

shAAV-213114
AAV-h-KIF7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KIF7 (kinesin family member 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ACLS; AGBK; EQYK340; HLS2; JBTS12; kinesin-like protein KIF7; UNQ340
Description (eCommerce)
KIF7 (kinesin family member 7) is the mammalian homolog of the zebrafish Cos2 protein. KIF7 has been shown to play an essential role in Hedgehog (Hh) signaling at the tip of cilia.
Description (Vector)
KIF7 encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.
Gene ID
374654
Gene Name (eCommerce)
kinesin family member 7
Gene Name (Vector)
kinesin family member 7
Gene Symbol
KIF7
HGNC ID
HGNC:30497
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2490
ORF Size (bp)
2490 bp
Protein Name (eCommerce)
Kinesin-like protein KIF7
RefSeq ID
NM_198525
RefSeq Synonyms
NM_198525, BC143461, BC112273, BC112271, BC104044,
Research Areas
Hedgehog Signaling,Neurobiology,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
KIF7 (kinesin family member 7) is the mammalian homolog of the zebrafish Cos2 protein. KIF7 has been shown to play an essential role in Hedgehog (Hh) signaling at the tip of cilia.
UniGene ID
Hs.513134
UniProt ID (eCommerce)
Q2M1P5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.