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human KIF4A shRNA silencing AAV

Name 
AAV-h-KIF4A-shRNA
Cat No 
shAAV-213103
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KIF4A.

shAAV-213103
AAV-h-KIF4A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KIF4A (kinesin family member 4A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
chromokinesin-A; chromosome-associated kinesin KIF4A; KIF4; KIF4G1; MRX100
Description (eCommerce)
The kinesin superfamily of proteins consists of over forty KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF14 silencing experiments suggest that KIF14 plays a multi-functional role in mitosis and cytokinesis. KIF4A has been shown to be essential for cytokinesis.
Description (Vector)
KIF4A encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.
Gene ID
24137
Gene Name (eCommerce)
kinesin family member 4A
Gene Name (Vector)
kinesin family member 4A
Gene Symbol
KIF4A
HGNC ID
HGNC:13339
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3384
ORF Size (bp)
3384 bp
Protein Name (eCommerce)
Chromosome-associated kinesin KIF4A
RefSeq ID
NM_012310
RefSeq Synonyms
NM_012310, BC050548,
Research Areas
Antigen Processing and Presentation,Axon Guidance,Cell Cycle,Cell Division,Cytoskeleton,Immunology,Neurobiology,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,neurobiology
Species
human
Target Sentence
The kinesin superfamily of proteins consists of over forty KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF14 silencing experiments suggest that KIF14 plays a multi-functional role in mitosis and cytokinesis. KIF4A has been shown to be essential for cytokinesis.
UniGene ID
Hs.648326
UniProt ID (eCommerce)
O95239

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.