human KIF18A shRNA silencing AAV

Name 
AAV-h-KIF18A-shRNA
Cat No 
shAAV-213073
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KIF18A.

shAAV-213073
AAV-h-KIF18A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KIF18A (kinesin family member 18A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
kinesin-like protein KIF18A; Marrow stromal KIF18A; MS-KIF18A; PPP1R99; protein phosphatase 1, regulatory subunit 99
Description (eCommerce)
The kinesin superfamily of proteins consists of over forty KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF18 has been demonstrated to be a microtubule depolymerase essential for chromosome alignment at the spindle equator.
Description (Vector)
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 (PubMed 15878648)).(supplied by OMIM, Aug 2008)
Gene ID
81930
Gene Name (eCommerce)
kinesin family member 18A
Gene Name (Vector)
kinesin family member 18A
Gene Symbol
KIF18A
HGNC ID
HGNC:29441
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2697
ORF Size (bp)
2697 bp
Protein Name (eCommerce)
Kinesin-like protein KIF18A
RefSeq ID
NM_031217
RefSeq Synonyms
NM_031217, BC048347,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cytoskeleton,Immunology,Kinase/Phosphatase,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
The kinesin superfamily of proteins consists of over forty KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF18 has been demonstrated to be a microtubule depolymerase essential for chromosome alignment at the spindle equator.
UniGene ID
Hs.301052
UniProt ID (eCommerce)
Q8NI77

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.