human KIAA1967 shRNA silencing AAV

Name 
AAV-h-KIAA1967-shRNA
Cat No 
shAAV-213057
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CCAR2.

shAAV-213057
AAV-h-KIAA1967-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCAR2 (cell cycle and apoptosis regulator 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cell cycle and apoptosis regulator protein 2; cell division cycle and apoptosis regulator protein 2; DBC.1; DBC1; DBC-1; DBIRD complex subunit KIAA1967; deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; KIAA1967; NET35; p30 DBC; p30 DBC protein; p30DBC
Description (eCommerce)
The DBC1 (Deleted in Breast Cancer Gene 1 protein) gene is located in a region frequently deleted in breast cancers. In its uncleaved form, DBC1 is localized to the nucleus. Upon cleavage by caspase activity, DBC1 becomes localized to the cytoplasm and functions to promote apoptosis. DBC1 has also been found to bind directly to the estrogen receptor alpha (ERalpha) hormone binding domain to modulate ERalpha expression and mediate hormone-independent breast cancer cell survival.
Gene ID
57805
Gene Name (eCommerce)
cell cycle and apoptosis regulator 2
Gene Name (Vector)
cell cycle and apoptosis regulator 2
Gene Symbol
CCAR2
HGNC ID
HGNC:23360
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2772
ORF Size (bp)
2772 bp
Protein Name (eCommerce)
Cell cycle and apoptosis regulator protein 2
RefSeq ID
NM_021174
RefSeq Synonyms
NM_021174, BC065495, BC018269,
Research Areas
Apoptosis,Cancer,Cell Cycle,DNA Damage/Repair,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,cancer
Species
human
Target Sentence
The DBC1 (Deleted in Breast Cancer Gene 1 protein) gene is located in a region frequently deleted in breast cancers. In its uncleaved form, DBC1 is localized to the nucleus. Upon cleavage by caspase activity, DBC1 becomes localized to the cytoplasm and functions to promote apoptosis. DBC1 has also been found to bind directly to the estrogen receptor alpha (ERalpha) hormone binding domain to modulate ERalpha expression and mediate hormone-independent breast cancer cell survival.
UniGene ID
Hs.654720
UniProt ID (eCommerce)
Q8N163

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.