human KDSR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KDSR.
shAAV-212863
AAV-h-KDSR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KDSR (3-ketodihydrosphingosine reductase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DHSR; FVT1; SDR35C1
Description (Vector)
KDSR catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy.
Gene ID
2531
Gene Name (Vector)
3-ketodihydrosphingosine reductase
Gene Symbol
KDSR
HGNC ID
HGNC:4021
ORF Size (aa)
999
ORF Size (bp)
999 bp
RefSeq ID
NM_002035
RefSeq Synonyms
NM_002035, BC008797,
Species
human
UniGene ID
Hs.74050
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.