human KCNN3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KCNN3.
shAAV-212768
AAV-h-KCNN3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KCNN3 (potassium calcium-activated channel subfamily N member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hSK3; KCa2.3; SK3; SKCA3
Description (Vector)
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
3782
Gene Name (Vector)
potassium calcium-activated channel subfamily N member 3
Gene Symbol
KCNN3
HGNC ID
HGNC:6292
ORF Size (aa)
1281
ORF Size (bp)
1281 bp
RefSeq ID
NM_002249
RefSeq Synonyms
NM_170782, NM_002249, NM_001204087, BC042147,
Species
human
UniGene ID
Hs.490765
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.