human KCNN2 shRNA silencing AAV

Name
AAV-h-KCNN2-shRNA

Cat No
shAAV-212766

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KCNN2.

shAAV-212766

AAV-h-KCNN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNN2 (potassium calcium-activated channel subfamily N member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

hSK2; KCa2.2; SK2; SKCa 2; SKCA2

Description (Vector)

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

3781

Gene Name (Vector)

potassium calcium-activated channel subfamily N member 2

Gene Symbol

KCNN2

HGNC ID

HGNC:6291

ORF Size (aa)

1740

ORF Size (bp)

1740 bp

RefSeq ID

NM_021614

RefSeq Synonyms

NM_170775, NM_021614, NM_001278204, BC117456, BC117454, BC015371,

Species

human

UniGene ID

Hs.98280

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.