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human KCNN1 shRNA silencing AAV

Name 
AAV-h-KCNN1-shRNA
Cat No 
shAAV-212765
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KCNN1.

shAAV-212765
AAV-h-KCNN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNN1 (potassium calcium-activated channel subfamily N member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hSK1; KCa2.1; SK1; SKCA1
Description (Vector)
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.
Gene ID
3780
Gene Name (Vector)
potassium calcium-activated channel subfamily N member 1
Gene Symbol
KCNN1
HGNC ID
HGNC:6290
ORF Size (aa)
1632
ORF Size (bp)
1632 bp
RefSeq ID
NM_002248
RefSeq Synonyms
NM_002248, BC075037,
Species
human
UniGene ID
Hs.158173

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.