human KCNJ4 shRNA silencing AAV

Cat. No: shAAV-212720

Availability: 6-8 weeks

Name: AAV-h-KCNJ4-shRNA

This is an AAV expressing shRNA for silencing of Human KCNJ4.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: KCNJ4
Gene Name: potassium voltage-gated channel subfamily J member 4
Gene ID: 3761
Gene Synonyms: HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3
ORF Size: 1338 bp
RefSeq#: NM_004981
Gene Description: Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.
UniGene ID: Hs.32505
HGNC ID: HGNC:6265