human KCNJ4 shRNA silencing AAV

Name
AAV-h-KCNJ4-shRNA

Cat No
shAAV-212720

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KCNJ4.

shAAV-212720

AAV-h-KCNJ4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNJ4 (potassium voltage-gated channel subfamily J member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3

Description (Vector)

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.

Gene ID

3761

Gene Name (Vector)

potassium voltage-gated channel subfamily J member 4

Gene Symbol

KCNJ4

HGNC ID

HGNC:6265

ORF Size (aa)

1338

ORF Size (bp)

1338 bp

RefSeq ID

NM_004981

RefSeq Synonyms

NM_152868, NM_004981, BC113508, BC113506,

Species

human

UniGene ID

Hs.32505

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.