human KCNJ3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KCNJ3.
shAAV-212719
AAV-h-KCNJ3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KCNJ3 (potassium voltage-gated channel subfamily J member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GIRK1; KGA; KIR3.1
Description (Vector)
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Gene ID
3760
Gene Name (Vector)
potassium voltage-gated channel subfamily J member 3
Gene Symbol
KCNJ3
HGNC ID
HGNC:6264
ORF Size (aa)
1506
ORF Size (bp)
1506 bp
RefSeq ID
NM_002239
RefSeq Synonyms
NM_002239, NM_001260510, NM_001260509, NM_001260508, BC022495,
Species
human
UniGene ID
Hs.591606
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.