human KCNAB1 shRNA silencing AAV

Name
AAV-h-KCNAB1-shRNA

Cat No
shAAV-212661

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KCNAB1.

shAAV-212661

AAV-h-KCNAB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNAB1 (potassium voltage-gated channel subfamily A member regulatory beta subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1; Kvb1.3

Description (Vector)

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.

Gene ID

7881

Gene Name (Vector)

potassium voltage-gated channel subfamily A member regulatory beta subunit 1

Gene Symbol

KCNAB1

HGNC ID

HGNC:6228

ORF Size (aa)

1206

ORF Size (bp)

1206 bp

RefSeq ID

NM_003471

RefSeq Synonyms

NM_172160, NM_172159, NM_003471, NM_001308222, NM_001308217, BC043166,

Species

human

UniGene ID

Hs.703187

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.