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human KCNA2 shRNA silencing AAV

Name 
AAV-h-KCNA2-shRNA
Cat No 
shAAV-212652
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KCNA2.

shAAV-212652
AAV-h-KCNA2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNA2 (potassium voltage-gated channel subfamily A member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
EIEE32; HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2
Description (Vector)
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
Gene ID
3737
Gene Name (Vector)
potassium voltage-gated channel subfamily A member 2
Gene Symbol
KCNA2
HGNC ID
HGNC:6220
ORF Size (aa)
1071
ORF Size (bp)
1071 bp
RefSeq ID
NM_004974
RefSeq Synonyms
NM_004974, NM_001204269, BC043564,
Species
human
UniGene ID
Hs.657199

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.