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human KAT2B shRNA silencing AAV

Name 
AAV-h-KAT2B-shRNA
Cat No 
shAAV-212627
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KAT2B.

shAAV-212627
AAV-h-KAT2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KAT2B (lysine acetyltransferase 2B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAF; CREBBP-associated factor; histone acetylase PCAF; histone acetyltransferase KAT2B; histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; Lysine acetyltransferase 2B; P/CAF; p300/CBP-associated factor; PCAF
Description (eCommerce)
PCAF (P300/CBP-associated factor) is a histone acetyltransferase (HAT) identified as a factor that associates with P300/CBP, a transcriptional coactivator of nuclear hormone receptors and other transcription factors.
Description (Vector)
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
Gene ID
8850
Gene Name (eCommerce)
lysine acetyltransferase 2B
Gene Name (Vector)
lysine acetyltransferase 2B
Gene Symbol
KAT2B
HGNC ID
HGNC:8638
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2499
ORF Size (bp)
2499 bp
Protein Name (eCommerce)
Histone acetyltransferase KAT2B
RefSeq ID
NM_003884
RefSeq Synonyms
NM_003884, BC070075, BC060823,
Research Areas
Acyltransferase,Cancer,Cell Cycle,Chromatin Remodeling,FoxO Signaling,Gene Expression,Histone Modification,Host-Virus Interactions,Notch Signaling,p53 Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,transcription_translation,signal_transduction,genetics,transcription_translation,infectious_disease,developmental_biology,signal_transduction,immunology,genetics,transcription_translation,cancer,infectious_disease
Species
human
Target Sentence
PCAF (P300/CBP-associated factor) is a histone acetyltransferase (HAT) identified as a factor that associates with P300/CBP, a transcriptional coactivator of nuclear hormone receptors and other transcription factors.
UniGene ID
Hs.533055
UniProt ID (eCommerce)
Q92831

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.