Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human JPH2 shRNA silencing AAV

Name 
AAV-h-JPH2-shRNA
Cat No 
shAAV-212592
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human JPH2.

shAAV-212592
AAV-h-JPH2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human JPH2 (junctophilin 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CMH17; JP2; JP-2; junctophilin type 2; junctophilin-2
Description (eCommerce)
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Junctophilins provide a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. Junctophilin-2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release, and contributes to the construction of skeletal muscle triad junctions [Taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BR39].
Description (Vector)
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.
Gene ID
57158
Gene Name (eCommerce)
junctophilin 2
Gene Name (Vector)
junctophilin 2
Gene Symbol
JPH2
HGNC ID
HGNC:14202
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2088
ORF Size (bp)
2088 bp
Protein Name (eCommerce)
Junctophilin-2
RefSeq ID
NM_020433
RefSeq Synonyms
NM_175913, NM_020433, BC172751,
Research Areas
Cardiac Development,Cardiology,Cardiomyopathy,Cardiovascular,Signal Transduction
Research Areas (Faceted)
cardiovascular,developmental_biology,signal_transduction
Species
human
Target Sentence
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Junctophilins provide a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. Junctophilin-2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release, and contributes to the construction of skeletal muscle triad junctions [Taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BR39].
UniGene ID
Hs.441737
UniProt ID (eCommerce)
Q9BR39

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.