Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human JAM3 shRNA silencing AAV

Name 
AAV-h-JAM3-shRNA
Cat No 
shAAV-212577
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human JAM3.

shAAV-212577
AAV-h-JAM3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human JAM3 (junctional adhesion molecule 3). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
JAM-2; JAM-3; JAMC; JAM-C; Junctional adhesion molecule 3; junctional adhesion molecule C
Description (eCommerce)
Junctional adhesion molecule C (JAM-C) participates in cell-cell adhesion. JAM-C is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form of JAM-C is a mediator of angiogenesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BX67].
Description (Vector)
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.
Gene ID
83700
Gene Name (eCommerce)
junctional adhesion molecule 3
Gene Name (Vector)
junctional adhesion molecule 3
Gene Symbol
JAM3
HGNC ID
HGNC:15532
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
933
Protein Name (eCommerce)
Junctional adhesion molecule C
RefSeq ID
NM_032801
RefSeq Synonyms
NM_032801, NM_001205329, BC012147,
Research Areas
Angiogenesis,Cardiovascular,Cytoskeleton,Immunology,Signal Transduction
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,signal_transduction
Species
human
Target Sentence
Junctional adhesion molecule C (JAM-C) participates in cell-cell adhesion. JAM-C is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form of JAM-C is a mediator of angiogenesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BX67].
UniGene ID
Hs.700882
UniProt ID (eCommerce)
Q9BX67

Recently Viewed Products

Ad-h-UBXN6

Cat No: ADV-229142

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.