human IRAK1 shRNA silencing AAV

Name
AAV-h-IRAK1-shRNA

Cat No
shAAV-212390

Availability
Immediate

This is an AAV expressing shRNA for silencing of Human IRAK1.

shAAV-212390

AAV-h-IRAK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IRAK1 (interleukin 1 receptor associated kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

interleukin-1 receptor-associated kinase 1; IRAK; IRAK-1; pelle; Pelle homolog

Description (eCommerce)

Interleukin-1 receptor-associated kinase 1 (IRAK1) is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B [taken from NCBI Entrez Gene (Gene ID: 3654)].

Description (Vector)

IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

3654

Gene Name (eCommerce)

interleukin 1 receptor associated kinase 1

Gene Name (Vector)

interleukin 1 receptor associated kinase 1

Gene Symbol

IRAK1

HGNC ID

HGNC:6112

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1902

ORF Size (bp)

1902 bp

Protein Name (eCommerce)

Interleukin-1 receptor-associated kinase 1

RefSeq ID

NM_001569

RefSeq Synonyms

NM_001569, NM_001025243, NM_001025242, BC054000, BC014963,

Research Areas

Apoptosis,Cytokine Signaling,EPO Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,Signal Transduction,Toll-like Receptor Signaling,Transcription Factor/Regulator,VEGF Signaling

Research Areas (Faceted)

cell_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

Species

human

Target Sentence

Interleukin-1 receptor-associated kinase 1 (IRAK1) is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B [taken from NCBI Entrez Gene (Gene ID: 3654)].

UniGene ID

Hs.522819

UniProt ID (eCommerce)

P51617

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.