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human INPP5D shRNA silencing AAV

Name 
AAV-h-INPP5D-shRNA
Cat No 
shAAV-212290
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human INPP5D.

shAAV-212290
AAV-h-INPP5D-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human INPP5D (inositol polyphosphate-5-phosphatase D). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145
Description (Vector)
INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene ID
3635
Gene Name (Vector)
inositol polyphosphate-5-phosphatase D
Gene Symbol
INPP5D
HGNC ID
HGNC:6079
ORF Size (aa)
3567
ORF Size (bp)
3567 bp
RefSeq ID
NM_005541
RefSeq Synonyms
NM_005541, NM_001017915, BC113582, BC113580, BC099920,
Species
human
UniGene ID
Hs.601911

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.