human IMPDH2 shRNA silencing AAV

Name
AAV-h-IMPDH2-shRNA

Cat No
shAAV-212246

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human IMPDH2.

shAAV-212246

AAV-h-IMPDH2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IMPDH2 (inosine monophosphate dehydrogenase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

IMPD2; IMPDH-II

Description (Vector)

IMPDH2 encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Gene ID

3615

Gene Name (Vector)

inosine monophosphate dehydrogenase 2

Gene Symbol

IMPDH2

HGNC ID

HGNC:6053

ORF Size (aa)

1545

ORF Size (bp)

1545 bp

RefSeq ID

NM_000884

RefSeq Synonyms

NM_000884, BC015567, BC012840, BC006124,

Species

human

UniGene ID

Hs.654400

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.