human ILKAP shRNA silencing AAV

Name 
AAV-h-ILKAP-shRNA
Cat No 
shAAV-212227
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ILKAP.

shAAV-212227
AAV-h-ILKAP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ILKAP (ILK associated serine/threonine phosphatase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ILKAP; ILKAP2; ILKAP3; integrin-linked kinase associated phosphatase; integrin-linked kinase-associated serine/threonine phosphatase 2C; PP2C-DELTA; PPM1O; protein phosphatase 2c, delta isozyme; protein phosphatase, Mg2+/Mn2+ dependent 1O
Description (eCommerce)
ILKAP is a protein phosphatase 2C that associates with integrin linked kinase (ILK) and inhibits ILK kinase activity and the ILK-GSK3beta signaling axis. It has been proposed that ILKAP inhibition of ILK activity may play an important role in inhibiting oncogenic transformation due to its influence on cell adhesion and growth factor signaling.
Description (Vector)
ILKAP is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.
Gene ID
80895
Gene Name (eCommerce)
ILK associated serine/threonine phosphatase
Gene Name (Vector)
ILK associated serine/threonine phosphatase
Gene Symbol
ILKAP
HGNC ID
HGNC:15566
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1179
ORF Size (bp)
1179 bp
Protein Name (eCommerce)
Integrin-linked kinase-associated serine/threonine phosphatase 2C
RefSeq ID
NM_030768
RefSeq Synonyms
NM_030768, BC006576,
Research Areas
Cell Cycle,Kinase/Phosphatase,Phosphatase,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
ILKAP is a protein phosphatase 2C that associates with integrin linked kinase (ILK) and inhibits ILK kinase activity and the ILK-GSK3beta signaling axis. It has been proposed that ILKAP inhibition of ILK activity may play an important role in inhibiting oncogenic transformation due to its influence on cell adhesion and growth factor signaling.
UniGene ID
Hs.92033
UniProt ID (eCommerce)
Q9H0C8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.