human IL17A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human IL17A.
shAAV-212057
AAV-h-IL17A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human IL17A (interleukin 17A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CTLA-8; CTLA8; IL-17; IL-17A; IL17
Description (Vector)
IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Gene ID
3605
Gene Name (Vector)
interleukin 17A
Gene Symbol
IL17A
HGNC ID
HGNC:5981
ORF Size (aa)
468
RefSeq ID
NM_002190
RefSeq Synonyms
NM_002190, BC067505, BC067504, BC067503, BC066253, BC066252, BC066251,
Species
human
UniGene ID
Hs.41724
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.