human IL12RB1 shRNA silencing AAV

Name
AAV-h-IL12RB1-shRNA

Cat No
shAAV-212036

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human IL12RB1.

shAAV-212036

AAV-h-IL12RB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IL12RB1 (interleukin 12 receptor subunit beta 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD212; IL-12R-BETA1; IL12RB; IMD30

Description (Vector)

IL12RB1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene ID

3594

Gene Name (Vector)

interleukin 12 receptor subunit beta 1

Gene Symbol

IL12RB1

HGNC ID

HGNC:5971

ORF Size (aa)

1989

ORF Size (bp)

1989 bp

RefSeq ID

NM_005535

RefSeq Synonyms

NM_153701, NM_005535, NM_001290024, NM_001290023, BC137406, BC137404, BC029121,

Species

human

UniGene ID

Hs.567294

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.