human IL10RA shRNA silencing AAV

Name
AAV-h-IL10RA-shRNA

Cat No
shAAV-212023

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human IL10RA.

shAAV-212023

AAV-h-IL10RA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IL10RA (interleukin 10 receptor subunit alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R

Description (Vector)

IL10RA is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Gene ID

3587

Gene Name (Vector)

interleukin 10 receptor subunit alpha

Gene Symbol

IL10RA

HGNC ID

HGNC:5964

ORF Size (aa)

1737

ORF Size (bp)

1737 bp

RefSeq ID

NM_001558

RefSeq Synonyms

NM_001558, BC028082,

Species

human

UniGene ID

Hs.504035

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.