human IL10RA shRNA silencing AAV

Cat. No: shAAV-212023

Availability: 6-8 weeks

Name: AAV-h-IL10RA-shRNA

This is an AAV expressing shRNA for silencing of Human IL10RA.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IL10RA
Gene Name: interleukin 10 receptor subunit alpha
Gene ID: 3587
Gene Synonyms: CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
ORF Size: 1737 bp
RefSeq#: NM_001558
Gene Description: IL10RA is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
UniGene ID: Hs.504035
HGNC ID: HGNC:5964