human IKZF2 shRNA silencing AAV

Name 
AAV-h-IKZF2-shRNA
Cat No 
shAAV-212018
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human IKZF2.

shAAV-212018
AAV-h-IKZF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IKZF2 (IKAROS family zinc finger 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ANF1A2; HELIOS; ikaros family zinc finger protein 2; zinc finger DNA binding protein Helios; zinc finger protein Helios; zinc finger protein, subfamily 1A, 2 (Helios); ZNF1A2; ZNFN1A2
Description (eCommerce)
Helios is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. Helios forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development [taken from NCBI Entrez Gene (Gene ID: 22807)].
Description (Vector)
IKZF2 encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
Gene ID
22807
Gene Name (eCommerce)
IKAROS family zinc finger 2
Gene Name (Vector)
IKAROS family zinc finger 2
Gene Symbol
IKZF2
HGNC ID
HGNC:13177
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1503
ORF Size (bp)
1503 bp
Protein Name (eCommerce)
Zinc finger protein Helios
RefSeq ID
NM_016260
RefSeq Synonyms
NM_016260, NM_001079526, BC028936,
Research Areas
Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Helios is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. Helios forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development [taken from NCBI Entrez Gene (Gene ID: 22807)].
UniGene ID
Hs.604950
UniProt ID (eCommerce)
Q9UKS7

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.