human IGF2R shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human IGF2R.
shAAV-211922
AAV-h-IGF2R-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human IGF2R (insulin like growth factor 2 receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD222; CI-M6PR; CIMPR; M6P-R; M6P/IGF2R; MPR 300; MPR1; MPR300; MPRI
Description (Vector)
IGF2R is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
Gene ID
3482
Gene Name (Vector)
insulin like growth factor 2 receptor
Gene Symbol
IGF2R
HGNC ID
HGNC:5467
ORF Size (aa)
7473
ORF Size (bp)
7473 bp
RefSeq ID
NM_000876
RefSeq Synonyms
NM_000876, BC172256,
Species
human
UniGene ID
Hs.487062
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.