human IBTK shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human IBTK.
shAAV-211743
AAV-h-IBTK-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human IBTK (inhibitor of Bruton tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Bruton agammaglobulinemia tyrosine kinase inhibitor; BTBD26; BTK-binding protein; BTKI; IBtk; inhibitor of Bruton tyrosine kinase; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-gamma
Description (eCommerce)
Inhibitor of Bruton tyrosine kinase (IBtk) acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. IBtk down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9P2D0].
Description (Vector)
IBTK binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
Gene ID
25998
Gene Name (eCommerce)
inhibitor of Bruton tyrosine kinase
Gene Name (Vector)
inhibitor of Bruton tyrosine kinase
Gene Symbol
IBTK
HGNC ID
HGNC:17853
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4017
ORF Size (bp)
4017 bp
Protein Name (eCommerce)
Inhibitor of Bruton tyrosine kinase
RefSeq ID
NM_015525
RefSeq Synonyms
NM_015525, NM_001300906, BC143745, BC143736, BC113698, BC113696,
Research Areas
B-cell Receptor Signaling,Immunology
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
Inhibitor of Bruton tyrosine kinase (IBtk) acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. IBtk down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9P2D0].
UniGene ID
Hs.306425
UniProt ID (eCommerce)
Q9P2D0
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.