human HTRA4 shRNA silencing AAV

Name
AAV-h-HTRA4-shRNA

Cat No
shAAV-211717

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HTRA4.

shAAV-211717

AAV-h-HTRA4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HTRA4 (HtrA serine peptidase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

HTRA4 encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.

Gene ID

203100

Gene Name (Vector)

HtrA serine peptidase 4

Gene Symbol

HTRA4

HGNC ID

HGNC:26909

ORF Size (aa)

1431

ORF Size (bp)

1431 bp

RefSeq ID

NM_153692

RefSeq Synonyms

NM_153692, BC057765,

Species

human

UniGene ID

Hs.661014

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.