human HSPE1 shRNA silencing AAV

Name 
AAV-h-HSPE1-shRNA
Cat No 
shAAV-211675
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HSPE1.

shAAV-211675
AAV-h-HSPE1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HSPE1 (heat shock protein family E (Hsp10) member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
10 kDa chaperonin; 10 kDa heat shock protein, mitochondrial; chaperonin 10; CPN10; early-pregnancy factor; EPF; epididymis secretory sperm binding protein; GROES; heat shock 10kD protein 1 (chaperonin 10); heat shock 10kDa protein 1; HSP10
Description (eCommerce)
HSPE1 is a eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. It binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P61604].
Description (Vector)
HSPE1 encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. HSPE1 and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.
Gene ID
3336
Gene Name (eCommerce)
heat shock protein family E (Hsp10) member 1
Gene Name (Vector)
heat shock protein family E (Hsp10) member 1
Gene Symbol
HSPE1
HGNC ID
HGNC:5269
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
309
Protein Name (eCommerce)
10 kDa heat shock protein, mitochondrial
RefSeq ID
NM_002157
RefSeq Synonyms
NM_002157, BC023518,
Research Areas
EGFR Signaling,Mitochondrion,Protein Folding,Signal Transduction
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
HSPE1 is a eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. It binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P61604].
UniGene ID
Hs.1197
UniProt ID (eCommerce)
P61604

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.