human HPS1 shRNA silencing AAV

Name
AAV-h-HPS1-shRNA

Cat No
shAAV-211502

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HPS1.

shAAV-211502

AAV-h-HPS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HPS1 (HPS1, biogenesis of lysosomal organelles complex 3 subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BLOC3S1; HPS

Description (Vector)

HPS1 encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is a component of three different protein complexes termed biogenesis of lysosome-related organelles complex (BLOC)-3, BLOC4, and BLOC5. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 1. Multiple transcript variants encoding distinct isoforms have been identified for this gene; the full-length sequences of some of these have not been determined yet.

Gene ID

3257

Gene Name (Vector)

HPS1, biogenesis of lysosomal organelles complex 3 subunit 1

Gene Symbol

HPS1

HGNC ID

HGNC:5163

ORF Size (aa)

2103

ORF Size (bp)

2103 bp

RefSeq ID

NM_000195

RefSeq Synonyms

NM_182639, NM_001322492, NM_001322491, NM_001322490, NM_001322489, NM_001322487, NM_001322485, NM_001322484, NM_001322483, NM_001322482, NM_001322481, NM_001322480, NM_001322479, NM_001322478, NM_001322477, NM_001322476, NM_001311345, NM_000195, BC166631, BC000175,

Species

human

UniGene ID

Hs.404568

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.