human HPRT1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HPRT1.
shAAV-211501
AAV-h-HPRT1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HPRT1 (hypoxanthine phosphoribosyltransferase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HGPRT; HGPRTase; HPRT; hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine-guanine phosphoribosyltransferase 1; testicular tissue protein Li 89
Description (eCommerce)
HPRT1 is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway [taken from NCBI Entrez Gene (Gene ID: 3251)].
Description (Vector)
HPRT1 is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.
Gene ID
3251
Gene Name (eCommerce)
hypoxanthine phosphoribosyltransferase 1
Gene Name (Vector)
hypoxanthine phosphoribosyltransferase 1
Gene Symbol
HPRT1
HGNC ID
HGNC:5157
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
657
Protein Name (eCommerce)
Hypoxanthine-guanine phosphoribosyltransferase
RefSeq ID
NM_000194
RefSeq Synonyms
NM_000194, BC000578,
Research Areas
Immunology,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Spermatogenesis
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,metabolism,neurobiology
Species
human
Target Sentence
HPRT1 is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway [taken from NCBI Entrez Gene (Gene ID: 3251)].
UniGene ID
Hs.412707
UniProt ID (eCommerce)
P00492
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.