human HOXD4 shRNA silencing AAV

Name
AAV-h-HOXD4-shRNA

Cat No
shAAV-211480

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HOXD4.

shAAV-211480

AAV-h-HOXD4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HOXD4 (homeobox D4). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HHO.C13; Hox-4.2; HOX-5.1; HOX4; HOX4B

Description (Vector)

HOXD4 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. HOXD4 is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined.

Gene ID

3233

Gene Name (Vector)

homeobox D4

Gene Symbol

HOXD4

HGNC ID

HGNC:5138

ORF Size (aa)

768

ORF Size (bp)

768 bp

RefSeq ID

NM_014621

RefSeq Synonyms

NM_014621, BC074797, BC016763,

Species

human

UniGene ID

Hs.591609

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.