human HOXB8 shRNA silencing AAV

Name
AAV-h-HOXB8-shRNA

Cat No
shAAV-211460

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HOXB8.

shAAV-211460

AAV-h-HOXB8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HOXB8 (homeobox B8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Hox-2.4; HOX2; HOX2D

Description (Vector)

HOXB8 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.

Gene ID

3218

Gene Name (Vector)

homeobox B8

Gene Symbol

HOXB8

HGNC ID

HGNC:5119

ORF Size (aa)

729

ORF Size (bp)

729 bp

RefSeq ID

NM_024016

RefSeq Synonyms

NM_024016, BC141560,

Species

human

UniGene ID

Hs.514292

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.