human HOXB5 shRNA silencing AAV

Name
AAV-h-HOXB5-shRNA

Cat No
shAAV-211457

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HOXB5.

shAAV-211457

AAV-h-HOXB5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HOXB5 (homeobox B5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HHO.C10; HOX2; Hox2.1; HOX2A; HU-1

Description (Vector)

HOXB5 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.

Gene ID

3215

Gene Name (Vector)

homeobox B5

Gene Symbol

HOXB5

HGNC ID

HGNC:5116

ORF Size (aa)

810

ORF Size (bp)

810 bp

RefSeq ID

NM_002147

RefSeq Synonyms

NM_002147, BC117247,

Species

human

UniGene ID

Hs.654456

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.