human HNRNPH2 shRNA silencing AAV

Name
AAV-h-HNRNPH2-shRNA

Cat No
shAAV-211378

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HNRNPH2.

shAAV-211378

AAV-h-HNRNPH2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2 (H’)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FTP3; hnRNPH'; HNRPH'; HNRPH2; MRXSB

Description (Vector)

HNRNPH2 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. HNRNPH2 is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed.

Gene ID

3188

Gene Name (Vector)

heterogeneous nuclear ribonucleoprotein H2 (H')

Gene Symbol

HNRNPH2

HGNC ID

HGNC:5042

ORF Size (aa)

1350

ORF Size (bp)

1350 bp

RefSeq ID

NM_019597

RefSeq Synonyms

NM_019597, NM_001032393, BC130345, BC130343,

Species

human

UniGene ID

Hs.632828

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.