human HNF1B shRNA silencing AAV

Name
AAV-h-HNF1B-shRNA

Cat No
shAAV-211326

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HNF1B.

shAAV-211326

AAV-h-HNF1B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HNF1B (HNF1 homeobox B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FJHN; HNF-1-beta; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1

Description (Vector)

HNF1B encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

6928

Gene Name (Vector)

HNF1 homeobox B

Gene Symbol

HNF1B

HGNC ID

HGNC:11630

ORF Size (aa)

1674

ORF Size (bp)

1674 bp

RefSeq ID

NM_000458

RefSeq Synonyms

NM_001304286, NM_001165923, NM_000458, BC017714,

Species

human

UniGene ID

Hs.191144

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.