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human HMGCS1 shRNA silencing AAV

Name 
AAV-h-HMGCS1-shRNA
Cat No 
shAAV-211284
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HMGCS1.

shAAV-211284
AAV-h-HMGCS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMG-CoA synthase; HMGCS; hydroxymethylglutaryl-CoA synthase, cytoplasmic
Description (eCommerce)
HMGCS1 (Hydroxymethylglutaryl-CoA synthase) condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q01581].
Gene ID
3157
Gene Name (eCommerce)
3-hydroxy-3-methylglutaryl-CoA synthase 1
Gene Name (Vector)
3-hydroxy-3-methylglutaryl-CoA synthase 1
Gene Symbol
HMGCS1
HGNC ID
HGNC:5007
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1563
ORF Size (bp)
1563 bp
Protein Name (eCommerce)
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
RefSeq ID
NM_002130
RefSeq Synonyms
NM_002130, NM_001330663, NM_001324224, NM_001324223, NM_001324222, NM_001324220, NM_001324219, NM_001098272, BC083514,
Research Areas
Brain Development,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
HMGCS1 (Hydroxymethylglutaryl-CoA synthase) condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q01581].
UniGene ID
Hs.397729
UniProt ID (eCommerce)
Q01581

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.