human HLA-F shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HLA-F.
shAAV-211237
AAV-h-HLA-F-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HLA-F (major histocompatibility complex, class I, F). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDA12; HLA-5.4; HLA-CDA12; HLAF
Description (Vector)
HLA-F belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. HLA-F exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
Gene ID
3134
Gene Name (Vector)
major histocompatibility complex, class I, F
Gene Symbol
HLA-F
HGNC ID
HGNC:4963
ORF Size (aa)
1041
ORF Size (bp)
1041 bp
RefSeq ID
NM_018950
RefSeq Synonyms
NM_018950, NM_001098479, NM_001098478, BC062991, BC009260,
Species
human
UniGene ID
Hs.519972
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.