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human HLA-DQA1 shRNA silencing AAV

Name 
AAV-h-HLA-DQA1-shRNA
Cat No 
shAAV-211220
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HLA-DQA1.

shAAV-211220
AAV-h-HLA-DQA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CELIAC1; DQ-A1; HLA-DQA
Description (Vector)
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
Gene ID
3117
Gene Name (Vector)
major histocompatibility complex, class II, DQ alpha 1
Gene Symbol
HLA-DQA1
HGNC ID
HGNC:4942
ORF Size (aa)
765
ORF Size (bp)
765 bp
RefSeq ID
NM_002122
RefSeq Synonyms
NM_002122, BC125045, BC125044, BC073977, BC008585,
Species
human
UniGene ID
Hs.387679

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.