human HJURP shRNA silencing AAV

Name 
AAV-h-HJURP-shRNA
Cat No 
shAAV-211202
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HJURP.

shAAV-211202
AAV-h-HJURP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HJURP (Holliday junction recognition protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
14-3-3-associated AKT substrate; FAKTS; fetal liver expressing gene 1; fetal liver-expressing gene 1 protein; hFLEG1; Holliday junction recognition protein; up-regulated in lung cancer 9; URLC9
Description (eCommerce)
Holliday junction recognition protein (HJURP) is a centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. HJURP acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. HJURP directly binds Holliday junctions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8NCD3].
Gene ID
55355
Gene Name (eCommerce)
Holliday junction recognition protein
Gene Name (Vector)
Holliday junction recognition protein
Gene Symbol
HJURP
HGNC ID
HGNC:25444
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2247
ORF Size (bp)
2247 bp
Protein Name (eCommerce)
Holliday junction recognition protein
RefSeq ID
NM_018410
RefSeq Synonyms
NM_018410, NM_001282963, NM_001282962, BC001940,
Research Areas
Cell Cycle,Cell Division
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Holliday junction recognition protein (HJURP) is a centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. HJURP acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. HJURP directly binds Holliday junctions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8NCD3].
UniGene ID
Hs.532968
UniProt ID (eCommerce)
Q8NCD3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.