human HISPPD2A shRNA silencing AAV

Name 
AAV-h-HISPPD2A-shRNA
Cat No 
shAAV-211049
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PPIP5K1.

shAAV-211049
AAV-h-HISPPD2A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PPIP5K1 (diphosphoinositol pentakisphosphate kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Diphosphoinositol pentakisphosphate kinase 1; HISPPD2A; histidine acid phosphatase domain containing 2A; histidine acid phosphatase domain-containing protein 2A; hsVIP1; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; inositol pyrophosphate synthase 1; insP6 and PP-IP5 kinase 1; IP6 kinase; IP6K; IPS1; VIP1; VIP1 homolog
Description (eCommerce)
PPIP5K1 is a bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6PFW1].
Description (Vector)
PPIP5K1 encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.
Gene ID
9677
Gene Name (eCommerce)
diphosphoinositol pentakisphosphate kinase 1
Gene Name (Vector)
diphosphoinositol pentakisphosphate kinase 1
Gene Symbol
PPIP5K1
HGNC ID
HGNC:29023
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4302
ORF Size (bp)
4302 bp
Protein Name (eCommerce)
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
RefSeq ID
NM_014659
RefSeq Synonyms
NM_014659, NM_001190214, NM_001130859, NM_001130858, BC057395, BC050263,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
PPIP5K1 is a bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6PFW1].
UniGene ID
Hs.156814
UniProt ID (eCommerce)
Q6PFW1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.