human HEXIM2 shRNA silencing AAV

Name
AAV-h-HEXIM2-shRNA

Cat No
shAAV-210984

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human HEXIM2.

shAAV-210984

AAV-h-HEXIM2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HEXIM2 (hexamethylene bisacetamide inducible 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

hexamethylene bis-acetamide inducible 2; hexamethylene bis-acetamide-inducible protein 2; hexamethylene-bis-acetamide-inducible transcript 2; L3; MAQ1 paralog; protein HEXIM2

Description (eCommerce)

HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA, HEXIM2 sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96MH2].

Gene ID

124790

Gene Name (eCommerce)

hexamethylene bisacetamide inducible 2

Gene Name (Vector)

hexamethylene bisacetamide inducible 2

Gene Symbol

HEXIM2

HGNC ID

HGNC:28591

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

861

ORF Size (bp)

861 bp

Protein Name (eCommerce)

Protein HEXIM2

RefSeq ID

NM_144608

RefSeq Synonyms

NM_144608, NM_001303444, NM_001303443, NM_001303442, NM_001303441, NM_001303440, NM_001303439, NM_001303438, NM_001303437, NM_001303436, BC025970, BC012474, BC003531,

Research Areas

RNA Binding,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,transcription_translation

Species

human

Target Sentence

HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA, HEXIM2 sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96MH2].

UniGene ID

Hs.56382

UniProt ID (eCommerce)

Q96MH2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.