human HDAC5 shRNA silencing AAV

Name 
AAV-h-HDAC5-shRNA
Cat No 
shAAV-210890
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human HDAC5.

shAAV-210890
AAV-h-HDAC5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HDAC5 (histone deacetylase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
antigen NY-CO-9; HD5; histone deacetylase 5; NY-CO-9
Description (eCommerce)
Histone deacetylase 5 (HDAC5) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9UQL6].
Description (Vector)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
10014
Gene Name (eCommerce)
histone deacetylase 5
Gene Name (Vector)
histone deacetylase 5
Gene Symbol
HDAC5
HGNC ID
HGNC:14068
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3369
ORF Size (bp)
3369 bp
Protein Name (eCommerce)
Histone deacetylase 5
RefSeq ID
NM_005474
RefSeq Synonyms
NM_005474, NM_001015053, BC051824,
Research Areas
Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Chromatin Remodeling,Epigenetic Regulation of Gene Expression,Golgi Apparatus,Histone Modification,Host-Virus Interactions,Immunology,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Histone deacetylase 5 (HDAC5) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9UQL6].
UniGene ID
Hs.438782
UniProt ID (eCommerce)
Q9UQL6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.