human HARS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HARS.
shAAV-210785
AAV-h-HARS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HARS (histidyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMT2W; HRS; USH3B
Description (Vector)
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
3035
Gene Name (Vector)
histidyl-tRNA synthetase
Gene Symbol
HARS
HGNC ID
HGNC:4816
ORF Size (aa)
1530
ORF Size (bp)
1530 bp
RefSeq ID
NM_002109
RefSeq Synonyms
NM_002109, NM_001289094, NM_001289093, NM_001289092, NM_001258042, NM_001258041, NM_001258040, BC080514, BC011807,
Species
human
UniGene ID
Hs.528050
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.