human HAP1 shRNA silencing AAV

Name
AAV-h-HAP1-shRNA

Cat No
shAAV-210778

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HAP1.

shAAV-210778

AAV-h-HAP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HAP1 (huntingtin associated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HAP2; hHLP1; HIP5; HLP

Description (Vector)

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

9001

Gene Name (Vector)

huntingtin associated protein 1

Gene Symbol

HAP1

HGNC ID

HGNC:4812

ORF Size (aa)

2016

ORF Size (bp)

2016 bp

RefSeq ID

NM_001079870

RefSeq Synonyms

NM_177977, NM_001079871, NM_001079870, BC156728,

Species

human

UniGene ID

Hs.158300

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.