human HAMP shRNA silencing AAV

Name
AAV-h-HAMP-shRNA

Cat No
shAAV-210772

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human HAMP.

shAAV-210772

AAV-h-HAMP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human HAMP (hepcidin antimicrobial peptide). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HEPC; HFE2B; LEAP1; PLTR

Description (Vector)

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

Gene ID

57817

Gene Name (Vector)

hepcidin antimicrobial peptide

Gene Symbol

HAMP

HGNC ID

HGNC:15598

ORF Size (aa)

255

RefSeq ID

NM_021175

RefSeq Synonyms

NM_021175, BC020612,

Species

human

UniGene ID

Hs.8821

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.