human GUCA2B shRNA silencing AAV

Name
AAV-h-GUCA2B-shRNA

Cat No
shAAV-210682

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GUCA2B.

shAAV-210682

AAV-h-GUCA2B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GUCA2B (guanylate cyclase activator 2B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GCAP-II; UGN

Description (Vector)

GUCA2B encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues.

Gene ID

2981

Gene Name (Vector)

guanylate cyclase activator 2B

Gene Symbol

GUCA2B

HGNC ID

HGNC:4683

ORF Size (aa)

339

RefSeq ID

NM_007102

RefSeq Synonyms

NM_007102, BC093781, BC093779, BC069301,

Species

human

UniGene ID

Hs.32966

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.