human GTF3C2 shRNA silencing AAV

Name 
AAV-h-GTF3C2-shRNA
Cat No 
shAAV-210654
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GTF3C2.

shAAV-210654
AAV-h-GTF3C2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GTF3C2 (general transcription factor IIIC subunit 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
general transcription factor 3C polypeptide 2; general transcription factor IIIC, polypeptide 2, beta 110kDa; TF3C-beta; TFIIIC 110 kDa subunit; TFIIIC110; TFIIIC-BETA; transcription factor IIIC 110 kDa subunit; transcription factor IIIC subunit beta
Description (eCommerce)
General transcription factor 3C polypeptide 2 (GTF3C2/TFIIIC110) is a subunit of the TFIIIC DNA-binding factor required for transcription of tRNA and 5S rRNA genes by RNA polymerase III. Human TFIIIC is composed of six subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, and TFIIIC35. The functional contribution of GTF3C2/TFIIIC110 to the TFIIIC complex has not been fully determined. TFIIIC that is not associated with GTF3C2/TFIIIC110 has been purified, and it has been proposed that GTF3C2/TFIIIC110 functions to activate the TFIIIC complex for RNA polymerase III transcription. Recent studies argue against this model of GTF3C2/TFIIIC110 function.
Gene ID
2976
Gene Name (eCommerce)
general transcription factor IIIC subunit 2
Gene Name (Vector)
general transcription factor IIIC subunit 2
Gene Symbol
GTF3C2
HGNC ID
HGNC:4665
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2736
ORF Size (bp)
2736 bp
Protein Name (eCommerce)
General transcription factor 3C polypeptide 2
RefSeq ID
NM_001521
RefSeq Synonyms
NM_001521, NM_001318909, NM_001035521, BC020981, BC000212,
Research Areas
Gene Expression,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
General transcription factor 3C polypeptide 2 (GTF3C2/TFIIIC110) is a subunit of the TFIIIC DNA-binding factor required for transcription of tRNA and 5S rRNA genes by RNA polymerase III. Human TFIIIC is composed of six subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, and TFIIIC35. The functional contribution of GTF3C2/TFIIIC110 to the TFIIIC complex has not been fully determined. TFIIIC that is not associated with GTF3C2/TFIIIC110 has been purified, and it has been proposed that GTF3C2/TFIIIC110 functions to activate the TFIIIC complex for RNA polymerase III transcription. Recent studies argue against this model of GTF3C2/TFIIIC110 function.
UniGene ID
Hs.75782
UniProt ID (eCommerce)
Q8WUA4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.