human GTF2IRD1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GTF2IRD1.
shAAV-210650
AAV-h-GTF2IRD1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GTF2IRD1 (GTF2I repeat domain containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BEN; binding factor for early enhancer; CREAM1; general transcription factor 3; general transcription factor III; general transcription factor II-I repeat domain-containing protein 1; GTF2I repeat domain-containing protein 1; GTF3; hMusTRD1alpha1; Muscle TFII-I repeat domain-containing protein 1; muscle TFII-I repeat domain-containing protein 1 alpha 1; MUSTRD1; MusTRD1/BEN; RBAP2; slow-muscle-fiber enhancer-binding protein; USE B1-binding protein; WBS; WBSCR11; WBSCR12; Williams-Beuren syndrome chromosomal region 11 protein; williams-Beuren syndrome chromosomal region 12 protein; Williams-Beuren syndrome chromosome region 11
Description (eCommerce)
GTF2IRD1/TFII-IRD1 possesses five helix-loop-helix GTF2I-like repeats and has been shown to bind the GUCE (GTF2IRD1 upstream response element) regulatory motif found in HOXC8, GOOSECOID, and TROPONININ (SLOW) genes. GTF2IRD1/TFII-IRD1 may be involved in skeletal muscle differentiation and myogenesis. Haploinsufficiency of GTF2IRD1/TFII-IRD1 results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.
Description (Vector)
GTF2IRD1 contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants.
Gene ID
9569
Gene Name (eCommerce)
GTF2I repeat domain containing 1
Gene Name (Vector)
GTF2I repeat domain containing 1
Gene Symbol
GTF2IRD1
HGNC ID
HGNC:4661
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2880
ORF Size (bp)
2880 bp
Protein Name (eCommerce)
General transcription factor II-I repeat domain-containing protein 1
RefSeq ID
NM_005685
RefSeq Synonyms
NM_016328, NM_005685, NM_001199207, BC018136,
Research Areas
Host-Virus Interactions,Neurobiology,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,infectious_disease,neurobiology,transcription_translation
Species
human
Target Sentence
GTF2IRD1/TFII-IRD1 possesses five helix-loop-helix GTF2I-like repeats and has been shown to bind the GUCE (GTF2IRD1 upstream response element) regulatory motif found in HOXC8, GOOSECOID, and TROPONININ (SLOW) genes. GTF2IRD1/TFII-IRD1 may be involved in skeletal muscle differentiation and myogenesis. Haploinsufficiency of GTF2IRD1/TFII-IRD1 results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.
UniGene ID
Hs.647056
UniProt ID (eCommerce)
Q9UHL9
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.