human GTF2H1 shRNA silencing AAV

Name
AAV-h-GTF2H1-shRNA

Cat No
shAAV-210639

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GTF2H1.

shAAV-210639

AAV-h-GTF2H1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GTF2H1 (general transcription factor IIH subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

basic transcription factor 2 62 kDa subunit; BTF2; BTF2 p62; epididymis secretory sperm binding protein; general transcription factor IIH polypeptide 1; general transcription factor IIH subunit 1; general transcription factor IIH, polypeptide 1, 62kDa; P62; TFB1; TFIIH; TFIIH basal transcription factor complex p62 subunit

Description (eCommerce)

GTF2H1 (general transcription factor IIH, polypeptide 1, 62kDa) is a component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA. When complexed to CAK, GTF2H1 is involved in RNA transcription by RNA polymerase II [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P32780].

Gene ID

2965

Gene Name (eCommerce)

general transcription factor IIH subunit 1

Gene Name (Vector)

general transcription factor IIH subunit 1

Gene Symbol

GTF2H1

HGNC ID

HGNC:4655

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1647

ORF Size (bp)

1647 bp

Protein Name (eCommerce)

General transcription factor IIH subunit 1

RefSeq ID

NM_005316

RefSeq Synonyms

NM_005316, NM_001142307, BC004452, BC000365,

Research Areas

Cancer,DNA Damage/Repair,Epigenetic Regulation of Gene Expression,Gene Expression,Host-Virus Interactions,mRNA Processing,RNA Processing,Transcription Factor/Regulator,Viral Carcinogenesis

Research Areas (Faceted)

cancer,cell_biology,genetics,transcription_translation,infectious_disease

Species

human

Target Sentence

GTF2H1 (general transcription factor IIH, polypeptide 1, 62kDa) is a component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA. When complexed to CAK, GTF2H1 is involved in RNA transcription by RNA polymerase II [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P32780].

UniGene ID

Hs.577202

UniProt ID (eCommerce)

P32780

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.