human GSTA3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GSTA3.
shAAV-210594
AAV-h-GSTA3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GSTA3 (glutathione S-transferase alpha 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GSTA3-3; GTA3
Description (Vector)
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.
Gene ID
2940
Gene Name (Vector)
glutathione S-transferase alpha 3
Gene Symbol
GSTA3
HGNC ID
HGNC:4628
ORF Size (aa)
669
ORF Size (bp)
669 bp
RefSeq ID
NM_000847
RefSeq Synonyms
NM_000847, BC020619,
Species
human
UniGene ID
Hs.102484
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.